Adrafinil ‘High’ | What You MUST Know

Have you heard about the Adrafinil ‘high’ and want to know more?

This guide will explain everything you must know about this fascinating topic. As legiimatet Modafinil is hard to obtain in many countries, Adrafinil, which is a liver-metabolized prodrug of Modafinil, is an extremely popular alternative.

Adrafinil is 100% legal in most places and offers users the chance to experience the world’s best nootropic, Modafinil, without the need for a prescription.

The downside is that Adrafinil has several additional side effects, and many people are curious about whether it can get you ‘high’ in some way, shape, or form.

P.S: This is the best place to buy Adrafinil online.

To clear up any confusion, we put together this comprehensive guide that will explain what you can expect when you take this powerful nootropic.

This is not medical or legal advice. This guide is strictly for entertainment purposes only. Always consult a medical professional before consuming any nootropic and always abide by the laws of your country. Please read my disclaimer page, too.

What is Adrafinil?

If you’ve never heard of Adrafinil before, it’s a ‘eugeroic’, or wakefulness-promoting agent that was discovered in 1974 by two scientists from Laboratoire L. Lafon SA of France. It was developed to treat conditions such as narcolepsy, which causes sufferers to fall asleep at inconvenient times.

Adrafinil is the parent drug, or ‘prodrug’, of Modafinil, meaning that it is metabolized in the liver into its active metabolite Modafinil after being ingested [1].

Adrafinil was released in France in 1985 under the brand name ‘Olmifon’ and was discontinued in 2011. However, generic Adrafinil is still produced by many companies around the world to this day.

Today, Adrafinil is only used as a nootropic. Individuals around the world take the over-the-counter supplement to enhance cognition and improve focus.

Adrafinil Smart Drug

Adrafinil Benefits

So, why do people take Adrafinil as opposed to Modafinil?


Modafinil is a highly regulated prescription-only drug that’s hard to find and buy in most countries. Where available, Modafinil is only prescribed to people suffering from conditions like narcolepsy, Shift Work Sleep disorder, and sleep apnoea.

Adrafinil, on the other hand, is 100% almost everywhere,  and is much easier and safer to find and buy. It offers similar pharmacological effects to Modafinil [2] and virtually the same benefits. The main difference is that Adrafinil is slower-acting and less potent.

In healthy individuals, Adrafinil helps people stay focused and concentrate for long periods, without feeling fatigued. This makes it popular with truck drivers, medical staff, and military aviators [3] as well as anyone engaged in challenging mental activities such as students preparing for exams, professors, academics, and researchers.

Adrafinil is also considered beneficial as a ‘nootropic’, which is a substance that can enhance a cognitive function like memory, concentration, focus, or information processing while also protecting the mind from stress [4].

A 300-600mg dose of Adrafinil offers the following benefits [5]:

  • 8+ hours of ‘laser-sharp’ concentration.
  • Increased attention span.
  • Improved motivation.
  • Enhanced alertness [6].
  • Better working memory [7].
  • And the inability to feel fatigued.

Curious about how Adrafinil works?

Adrafinil increases histamine levels in the brain and gives you a powerful feeling of alertness that lasts for up to eight hours [8]. This is less than the 12+ hours you can expect from Modafinil, but still pretty darn good. Adrafinil acts as a potent appetite suppressant and prevents you from feeling fatigued [9], letting you work longer than you might otherwise be able to.

Adrafinil helps improve working and episodic memory [10] by binding to the brain’s dopamine transporter and preventing the reuptake of dopamine [11]. This increases the amount of dopamine, serotonin, and norepinephrine in the brain, and boosts memory.

Adrafinil also reduces reactivity to fear stimuli in the amygdala, which is the region of the brain involved in anxiety [12]. This improves the quality of your work or study, even if you are under a high level of stress.

Adrafinil Side Effects and Safety

Just because Adrafinil might be 100% legal where you live doesn’t mean that using it is risk-free. Here’s what you need to know…

To start with, don’t take Adrafinil if you are pregnant or nursing, or are at risk of conditions like depression, diabetes, or psychiatric disorders. Adrafinil can reduce the efficacy of hormonal birth control and can lead to rapid intoxication and blackouts when taken with alcohol.

As Adrafinil converts to Modafinil in the liver, both nootropics produce almost identical side effects. While there haven’t been any studies into what happens when Adrafinil is taken ‘off-prescription’ as a nootropic, there have been studies into what happens when healthy individuals take Modafinil, which is Adrafinil’s active metabolite.

One study looked at what happened when Modafinil was given to patients who had been incorrectly diagnosed with narcolepsy, i.e. non-sufferers. It found that Modafinil caused a range of side effects including [13]:

  • Headaches
  • Dehydration
  • Stomach pain
  • Nausea
  • Anxiety
  • Insomnia
  • Lumbago
  • Diarrhea
  • Dyspepsia
  • Rhinitis
  • Vertigo
  • Dry mouth
  • Back pain

Those are the main side effects you can expect when you take Adrafinil, however, how your body responds to it depends on a whole host of factors including your current physical condition, genetic factors, and the dose.

You can minimize or mitigate some side effects by taking the following precautions.

  • Drink plenty of water throughout the day to avoid becoming dehydrated and developing a headache and/or stomach pains.
  • Take the dose earlier to avoid experiencing sleeplessness or insomnia.
  • Lower your dosage to minimize any side effects you may experience.

Adrafinil also has several side effects not found in Modafinil.

These are:

  • Skin irritation.
  • Orofacial dyskinesia (which is where the mouth and face move involuntarily in repetitive ways [14].
  • Elevated liver enzyme values [15].

As Adrafinil is metabolized in the liver, it places more strain on the liver compared with Modafinil. While liver damage is associated with prolonged Adrafinil use, it can be minimized in several ways.

Firstly, as 300mg of Adrafinil is equivalent to 100mg of Modafinil, it’s best to limit your dose to 300mg or less per day and use it every other day up to a maximum of three times per week.

After two weeks, take one week off and use a milk thistle (Silybum marianum) supplement to detoxify your liver. Silymarin acts as an antioxidant by reducing free radical production and helps prevent toxins from binding to your liver [16].

All in all, Adrafinil is pretty safe when you take to a 300-600mg dose and you shouldn’t have much trouble.

But again, we aren’t doctors and this isn’t medical advice, so if you are in any doubt about how Adrafinil may interact with your existing medical conditions or medications, you should contact your doctor as soon as possible.

Adrafinil ‘High’ | What You MUST Know

So, the question at hand:

Does Adrafinil make you ‘high’?

The short answer is no, not on its own.

Adrafinil is best thought of as a slower-acting alternative to Modafinil. When you take it on an empty stomach, you’ll notice its effects start to become apparent after 30-45 minutes.

Adrafinil’s effects are much milder than Modafinil and it doesn’t last as long. Instead of feeling ‘high’, you get a strong burst of focus and concentration that lasts up to eight hours. Adrafinil helps get rid of ‘brain fog’ and lets you focus on your work or study without procrastinating. In short, you can get more work done and increase your productivity.

While we’re not aware of any medical or anecdotal evidence that Adrafinil produces a sense of being ‘high’, new users should be especially vigilant when taking this nootropic. They may start with 150mg (half a capsule) and gauge their body’s response before deciding whether to take a full, 300-600mg dose.

In some cases, Adrafinil may make you feel sleepy the first couple of times you take it. We recommend taking Adrafinil every other day, for a maximum of three times per week. By your third dose (the sixth day) you should find that Adrafinil gives you the feeling of alertness that you wanted to take it for.

Most users find that Adrafinil’s effect lasts for around eight hours and that small doses of caffeine, such as a cup of coffee, help ‘re-energize’ the effect and bring back their sense of focus and clarity.

You should avoid consuming energy drinks when taking Adrafinil, as they contain things like yohimbine and synephrine that can interact adversely with the nootropic.

In summary, Adrafinil won’t make you feel ‘high’ and you shouldn’t be concerned.

Adrafinil Dosage

Modafinil vs. Adrafinil

Adrafinil vs. Modafinil.

What’s the difference?

The main differences between these nootropics are that Modafinil is faster-acting, more potent, and longer-lasting than Adrafinil yet is a prescription medication in most countries and much harder to get hold of.

Adrafinil is a slower-acting alternative to Modafinil that’s 100% legal in most places and easier to get hold of without any hassles.

If you compare both nootropics like-for-like (with 300mg of Adrafinil equaling 100mg of Modafinil) then the benefits and side effects are pretty similar.

However, Adrafinil has several side effects not found with Modafinil such as elevated liver enzyme values, skin irritation, and orofacial dyskinesia.

The price of both nootropics is the same when you account for differences in dosage sizes.

Where to Buy Adrafinil Online | 2020 Guide

Even if Adrafinil is 100% legal where you live, you can’t just head down to your local pharmacy or supplement store and buy some; you need to go online.

We’ve reviewed the top suppliers and have found AbsorbYourHealth to be the most reliable Adrafinil vendor around.

These guys entered the smart drug scene in 2011 and have a solid track record for supplying top-quality Adrafinil worldwide.

We rate them highly for the following reasons:

  • Rigorous 3rd Party Testing: AbsorbYourHealth tests every batch of Adrafinil they offer with an independent lab to ensure that they only ship top-grade nootropics.
  • International Shipping to over 100 countries: They offer free shipping on all U.S. orders over $70 and all International orders over $200. All orders are shipped within 2-3 business days and come with free tracking.
  • Fair returns policies: US customers have 90 days to return their product for a full refund if they aren’t entirely satisfied with their orders. If there is an issue with USPS, they can ask for a full refund or free reshipping in the highly unlikely event that an order does get through.

If you’re looking for a fast, reliable way to buy Adrafinil…AbsorbYourHealth is highly recommended.

Adrafinil ‘High’ | Verdict

If you were curious about whether Adrafinil makes you feel ‘high’ — hopefully this guide has cleared up the issue and answered all your questions!

Adrafinil is a slower-acting alternative to Modafinil that puts more strain on your liver but is 100% legal in most countries. Unless you start chugging energy drinks, you shouldn’t get ‘high’ with Adrafinil, no matter how much you take.


With a proper Adrafinil dosage, you should feel impressive nootropic effects, like enhanced cognition and improved focus.


  1. Milgram, N.W., Callahan, H. and Siwak, C. (1999), Adrafinil: A Novel Vigilance Promoting Agent. CNS Drug Reviews, 5: 193-212. doi:10.1111/j.1527-3458.1999.tb00100.x
  2. Murillo-Rodríguez E, Barciela Veras A, Barbosa Rocha N, Budde H, Machado S. An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil. ACS Chem Neurosci. 2018;9(2):151-158. doi:10.1021/acschemneuro.7b00374
  3. Ooi T, Wong SH, See B. Modafinil as a Stimulant for Military Aviators. Aerosp Med Hum Perform. 2019;90(5):480-483. doi:10.3357/AMHP.5298.2019
  4. Giurgea C. Vers une pharmacologie de l’activité intégrative du cerveau. Tentative du concept nootrope en psychopharmacologie [Pharmacology of integrative activity of the brain. Attempt at nootropic concept in psychopharmacology]. Actual Pharmacol (Paris). 1972;25:115-156.
  5. Siwak CT, Callahan H, Milgram NW. Adrafinil: effects on behavior and cognition in aged canines. Prog Neuropsychopharmacol Biol Psychiatry. 2000;24(5):709-726. doi:10.1016/s0278-5846(00)00103-2
  6. Brühl AB, d’Angelo C, Sahakian BJ. Neuroethical issues in cognitive enhancement: Modafinil as the example of a workplace drug?. Brain Neurosci Adv. 2019;3:2398212818816018. Published 2019 Feb 15. doi:10.1177/2398212818816018
  7. Battleday RM, Brem AK. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. Eur Neuropsychopharmacol. 2015;25(11):1865-1881. doi:10.1016/j.euroneuro.2015.07.028
  8. Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A. Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett. 2003;339(2):143-146. doi:10.1016/s0304-3940(03)00006-5
  9. Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001;63(6):637-672. doi:10.1016/s0301-0082(00)00039-3
  10. Zolkowska D, Jain R, Rothman RB, et al. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther. 2009;329(2):738-746. doi:10.1124/jpet.108.146142
  11. Rasetti, R., Mattay, V. S., Stankevich, B., Skjei, K., Blasi, G., Sambataro, F., Arrillaga-Romany, I. C., Goldberg, T. E., Callicott, J. H., Apud, J. A., & Weinberger, D. R. (2010). Modulatory effects of modafinil on neural circuits regulating emotion and cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2101–2109.
  12. Minzenberg MJ, Carter CS. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology. 2008;33(7):1477-1502. doi:10.1038/sj.npp.1301534
  13. Lopes E, Pereira D, da Silva Behrens NS, et al. Cataplexy as a side effect of modafinil in a patient without narcolepsy. Sleep Sci. 2014;7(1):47-49. doi:10.1016/j.slsci.2014.07.015
  14. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord. 2004;19(8):965-966. doi:10.1002/mds.20154
  15. Ballas CA, Kim D, Baldassano CF, Hoeh N. Modafinil: past, present and future. Expert Rev Neurother. 2002;2(4):449-457. doi:10.1586/14737175.2.4.449
  16. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-1432. doi:10.1002/ptr.3207


After utilizing nootropics for the better part of a decade, I realized the potent results these products produce -- with regards to productivity and cognitive enhancement. Soon thereafter, I became obsessed with finding the premier smart drugs on the market. Then using them to improve my life. When I'm not devouring everything I can about nootropics and the science behind why they work, you'll find me traveling around the world or in the gym.

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